LL-37 5mg
LL-37 is a cationic, amphipathic antimicrobial peptide derived from the cathelicidin family, with a 37-amino acid sequence encoded by the hCAP18 precursor. It exhibits broad-spectrum antimicrobial activity, including against Gram-positive and Gram-negative bacteria, fungi, and viruses, by disrupting microbial membrane integrity and inducing intracellular perturbations.
LL-37 engages immune modulatory pathways through interaction with pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and formyl peptide receptor-like 1 (FPRL1), resulting in the regulation of inflammatory cytokine release and chemotaxis in non-human test subjects. Additionally, it enhances angiogenesis and epithelial cell migration, contributing to wound repair processes. The peptide also plays a role in modulating the immune response in animal test subjects by neutralizing lipopolysaccharides (LPS), thus attenuating endotoxin-induced inflammatory pathways.
Research on LL-37 further reveals its bifunctional role in oncological contexts, where it may exert both tumor-suppressive and tumor-promoting effects, contingent upon the surrounding microenvironment. Due to its multifaceted biological activities, LL-37 is of significant interest in preclinical studies aimed at investigating its potential therapeutic applications in combating microbial resistance and modulating inflammatory responses in non-human test subjects.
How does injectable LL-37 work in the body?
LL-37 acts directly on pathogens by disrupting their cell membranes, helping the body fight infections. It also regulates inflammatory responses and promotes the repair of damaged tissues.
Main benefits of injectable LL-37 (especially for athletes and active individuals):
- Antimicrobial effects: Helps fight bacteria, viruses and fungi.
- Improving wound healing: Promotes tissue regeneration and accelerates the repair of damaged muscles.
- Reducing inflammation: Helps regulate the immune response and reduce inflammation.
- Immune support: Strengthens the body’s defense mechanisms, which can be useful during intense training.
- Protection against infections: Particularly suitable for athletes at increased risk of bacterial and viral infections.
Possible uses of injectable LL-37:
It is used in research to support the immune system, heal wounds, and fight chronic infections. It is being explored in the sports community to speed up recovery and prevent infections during intense training.
Dosage of injectable LL-37:
The dosages listed below are purely based on anecdotal user experiences and do not serve as medical advice or expert recommendation:
- Beginners: 100 mcg 1-2 times daily
- Intermediate: 200 mcg 1-2 times daily
- Advanced: 300 mcg 1-2 times daily
Administration can be subcutaneous (under the skin) or intramuscular, with exact protocols depending on individual goals and tolerability.
Side effects:
They may include mild irritation at the injection site, temporary fatigue, mild digestive discomfort or local reactions. Each organism may react individually.
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