CJC-1295 DAC 5mg

CJC-1295 with DAC is a synthetic peptide, analog of the growth hormone-releasing hormone. Though CJC-1295 without DAC has the same effect and stimulates the production and secretion of growth hormone, the addition of Drug Affinity Complex (DAC) is what increases its half-life allowing it to act longer and more potently.

Research also suggests that CJC-1295 with DAC stimulates insulin-like growth factor 1 (IGF-1) and plays a part in a number of physiological processes.

As previously mentioned, CJC-1295+ DAC was developed by ConjuChem Biotechnologies, where the company modified Growth Hormone Releasing Hormone (GHRH), to preserve its benefits while steering clear of the negative effects.

One such modification consists of only the first 29 amino acids of GHRH and is called CJC-1295. Additional effort was then made to prolong its half-life, eliminate some harmful effects, improve its action duration, and generally get a more soluble GH secretagogue, that would be easier to produce in larger quantities, while preserving its effectiveness.

Some might say that CJC-1295 is similar to other GH analogues (such as Sermorelin), but this is not entirely true. Though they are similar, the two peptides differ in structure and mechanism of action.

DAC (drug affinity complex) was added to the original peptide compound to protect it while it circulates the bloodstream. This led to the increased half-life of the peptide and prolonged action.

CJC-1295+DAC – Research, Studies and Potential Effects

Growth Hormone

Numerous lab studies in mice showed CJC-1295 as an effective way of promoting the release of GH. What researchers saw from the studies was the potency of a single dose to increase GH levels in mice by 2 and up to 10 times! What’s even more surprising is that the peak of this GH secretion in mice was reached approximately 2 hours after the administration, and lasted a full 6 days.

Why researchers find CJC-1295 so interesting and worth testing is that its application preserved the normal physiologic GH release. What this means is they were able to see circadian peaks and valleys present in normal GH release cycles. Preserving this rhythm while simultaneously increasing the amount of the hormone in the bloodstream is what’s ensuring minimal side effects and irregularities.

CJC-1295+ DAC studies were able to show its ability to preserve psychological effects GH has on protein synthesis, myocardial function, bone density, blood sugar, lipid metabolism etc, in mice.

Growth

Since CJC-1295 helps maintain normal circadian rhythm and promotes normal GH release, numerous studies in mice showed its potential in normalizing growth issues in mammalian species.

The only limiting factor to its therapeutic application is its short half-life, which is why scientists are experimenting with adding DAC to improve it.

(In)Fertility

Way back in the 90’s, scientists made the connection between ovarian cycle stimulation and ovulation and IGF-1 hormones (as well as the release of GH). Furthermore, an animal study in superovulation proved that the levels of IGF-1 and GH rose significantly during an ovulation.

This leaves an open question as to if administration of CJC-1295 in infertile animal test subjects has the potential to reverse their infertility. Some additional speculations have been made regarding male infertility and CJC’s potential to regulate sperm production. Sadly, by the time of this writing, no such studies have been done, but we’ll be looking forward to seeing them in the future.