SNAP-8 200mg

SNAP-8 is also known as Acetyl Octapeptide – 3, Caprylyl Glycol. Octapeptide is a strand of 8 amino acids. SNAP-8 peptide has a 98% purity making it highly effective and one of the top peptides on the market. Please note that our peptides are sold for research purposes only.

We pride ourselves on our exceptional quality products and affordable prices. The peptide comes in a lyophilized powder form which can be easily dissolved in water. Snap-8 peptide is produced synthetically in a cGMP compliant facility. In a clinical study, snap-8 was compared to Argireline (Acetyl Hexapeptide 8)

Synaptosomal-associated protein 8, or the SNAP-8 peptide, is a synthetic octapeptide analog of the N-terminal end of the SNAP-25 peptide. The peptide is made of eight amino acids. It is acetylated at the N-terminus and amidated at the C-terminus, which leads to the following structure: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2.

This peptide was developed to compete with the SNAP-25 protein to bind with the vehicle-associated membrane proteins. The SNAP-25 protein, which stands for Synaptosomal-Associated Protein of 25 kDa, is considered a key component in neurotransmitter release. It normally interacts with vehicle-associated membrane proteins to facilitate the fusion of vesicles with the cell membrane, releasing their contents into the synaptic gap. Such a vesicle-associated membrane protein is thought to be synaptic vesicle protein Synaptotagmin 1 (Syt1). Synaptotagmin 1 (Syt1) serves as a calcium sensor and is deemed crucial for regulating neurotransmitter release in response to changes in calcium ion concentrations inside nerve cells.

Molecular docking experiments posited that SNAP-8 and other peptides might bind to the C2A–C2B interface, primarily driven by hydrophobic contacts, suggesting a plausible site for inhibitory action on Syt1. The C2A and C2B regions are parts of the protein structure of Synaptotagmin 1 involved in calcium binding and membrane interaction. The binding at this interface by SNAP-8 suggests that the peptide might interfere with Synaptotagmin 1’s ability to respond to calcium signals, potentially disrupting normal neurotransmission. Once the SNAP-8 peptide binds with these proteins, it appears to destabilize the formation of the Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor (SNARE) complex.